Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany

Psoriasis is a common inflammatory skin disorder with strong impact on patients’ QOL. The most psoriasis form, vulgaris (PsV), characterized by demarcated, erythematous, raised plaques along silvery scales. Up to 30% of patients PsV develop an joint disease named psoriatic arthritis (PsA) (Mease et al., 2013; Reich 2009). and PsA are genetically complex diseases >65 susceptibility loci identified in one or both subtypes (Tsoi 2017).